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That said, HRT isnt for everyone
Knockdown of VMAT2 in mice disturbs DA vesicle storage and leads to mild and progressive DA neurodegeneration, accompanied by elevated levels of cysteinyl-DAQs adducts, suggesting enhanced DA oxidation and DAQ toxicity [45]
Patients expect tailored experiences, and technology now makes this possible at scale
Whether or not injectable LGD-4033 has that same drawback remains to be seen
The most serious risk, lactic acidosis, is extremely rare (estimated at 1-5 cases per 100,000 patient-years) and occurs almost exclusively in patients with severe kidney impairment or acute illness
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