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GHK-Cu's most extensively documented biological activity involves its profound effects on wound healing and tissue regeneration, where it orchestrates multiple phases of the repair process through coordinated molecular mechanisms
93,94,95 was used for overlaying the metabolite concentration data to map changes in metabolism at different phases to a global/systems scale
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Samples were maintained at cryogenic temperatures using a closed cycle liquid He coldhead cryostat (15 K) to minimize radiation damage and maintain an inert sample environment
Interestingly, transcriptome analysis showed that in NPCs derived from IMPA1 -mutated patients the most upregulated genes involved in cell cycle arrest were p15INK4B and p16INK4A while those linked to apoptosis were CASP4 and p16INK4A
