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Long-Term Safety: What Our Patients Should Know Clinical studiesincluding those lasting two years or longerhave shown that semaglutide GLP-1 is generally well-tolerated and effective for both weight loss and blood sugar control

The supplement strategies that work with tirzepatide apply equally well to retatrutide, with electrolytes being perhaps the most critical addition

The most optimal outcomes stem from a collaborative approach

Given the lack of separation from sham on the primary endpoints in parts A and B, part C of the study was terminated early (2021)

Weight loss in turn improves blood pressure, lipid profile, insulin sensitivity, and systemic inflammatory markers, mechanisms that likely contribute to the 20% relative reduction in MACE observed in the SELECT trial despite the absence of diabetes in the enrolled population