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GLP-1 agonists have proven to be very effective in helping people lose weight, which is a large part of their appeal
For constipation management, increasing soluble fibre gradually (such as ispaghula/psyllium) is recommended by NICE guidance for IBS, while excessive insoluble fibre should generally be avoided as it may worsen symptoms
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Long duration of trial needed (Outcome) Any clinical trial investigating an effect on the change in cancer risk will logically have to take place over a time period in which the carcinogenic environment has been modified for a sufficient amount of time
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