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The same compound that repairs a torn Achilles tendon in a rat also appears to attenuate the neurological consequences of dopamine depletion, pointing to a shared upstream mechanism that remains an active area of investigation
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In the nucleus, HIF-1 drives the up-regulation of glycolysis gene transcription
A 2015 study by Huang and colleagues in Drug Design, Development and Therapy used a rat alkali-burn model (n=10 per group) and HUVECs treated with BPC-157 at 200800 ng/mL, reporting accelerated wound closure with enhanced granulation tissue, reepithelialization, and dermal remodeling by day 18, alongside increased endothelial migration and vascular tube formation in vitro via ERK1/2 phosphorylation though the abstract does not report numeric % wound closure or p-values
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