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The SURPASS trials showed tirzepatide achieved 22% average weight reduction versus semaglutide's 14% at comparable doses
In addition to GLP-1R/GIPR dual-target drugs, GLP-1R/GCGR dual-target and GLP-1R/GIPR/GCGR triple-target drugs are the focus of ongoing multi-target GLP-1 drug development
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A Nature Medicine analysis of the structural and pharmacological data provided mechanistic context for these outcomes, linking the superior efficacy to the additive contributions of all three receptor pathways [9]
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