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That same clinical evidence base also shows that these medications don't work equally for every patient, that gastrointestinal side effects are common especially during dose escalation, and that weight tends to return when medication is discontinued without sustained lifestyle changes

At the doses present in Empower formulations, niacinamide provides modest supplementation that may support mitochondrial function and energy metabolism

MNT spoke with Jeffrey Zarin, MD, an orthopedic surgeon specializing in joint replacement surgery at Cedars-Sinai Orthopaedics in Los Angeles, CA, about this study, who commented that his first reaction was to be cautious about over-interpreting its findings

Then progress slows

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