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439 Due to the limited expression of IL-22 receptor on epithelial cells, such as hepatocytes, IL-22 could serve as a specific target for preventing hepatocyte death and promoting hepatocyte proliferation without affecting immune cells
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Patients at highest risk include those in the dose-escalation phase, experiencing active gastrointestinal symptoms (nausea, vomiting, bloating), those with known gastroparesis, or those taking concurrent medications that further delay gastric emptying (such as opioids)
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