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Unfortunately, some patients have difficulty absorbing an adequate amount of vitamin 12 because they do not produce enough stomach acid due to a condition called autoimmune atrophic gastritis which can cause a deficiency of vitamin B12

Intestinal motility dysfunction is a key contributor to constipation, leading to prolonged retention of intestinal contents and increased water reabsorption, which results in harder, drier stools (20, 21)

When consumed as a standard powder or tablet, the fragile tripeptide structure is rapidly degraded by gastric enzymes (such as gamma-glutamyltransferase) and undergoes aggressive first-pass hepatic metabolism, reducing the amount of GSH in the blood [2]

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doi: 10.1038/s41593-025-01971-w 15 DevkotaP