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Description

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Effect of once-weekly exenatide in patients with type 2 diabetes mellitus with and without heart failure and heart failurerelated outcomes: Insights from the EXSCEL trial

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In addition to the classical functions of cAMP, the cAMP/CREB pathway can induce the expression of insulin receptor substrate 2 (IRS2) and promote -cell survival, further demonstrating the protective effects of GLP-1 analogs on -cells [7] [8] [9] [10]

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Antioxidants like glutathione and CoQ10 protect against oxidation by degrading ROS into inert compounds

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