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GCL, heterodimer made up of the heavy sub unit (73 kDa) has the catalytic activity (GCLC), and is the site of GSH feed back inhibition The light (30 kDa) or modifier (GCLM) sub unit, alter, or regulate the activity of the holoenzyme Glutamate cysteine ligase (GCL) L-glutamate + L-cysteine + ATP -L-glutamyl-L-cysteine + ADP + Pi GCL is regultate physiologically by : Feed back competitive inhibition by GSH The availability of its precurser, L-cysteine
A modified version of exenatide was developed by adding lysine residues to the C-terminal (lixisenatide)
PD leads to debilitating motor and non-motor symptoms and is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra
L-Carnitine is a quaternary amine synthesized in the body from lysine and methionine, and found abundantly in meat (the name derives from the Latin "carnus" flesh)
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