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Glucagon is traditionally thought of as a "counter-regulatory" hormone that raises blood sugar
It is produced by modifying the Cterminus of the MTII scaffold replacing the terminal amide with a hydroxyl group yielding a related cyclic peptide with a distinct receptorselectivity profile while retaining the lactambridged, enzymatically stable architecture of its parent compound
Of these, 44 completed the trial and 5 withdrew
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