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doi:10.1093/emboj/cdg585
The European Association for the Study of the Liver (EASL) clinical practice guidelines on Wilson disease note that hepatic copper exceeding 250 mcg/g dry weight is a strong diagnostic criterion for Wilson disease, but subclinical copper accumulation can begin at much lower thresholds in patients with cholestatic or cirrhotic liver disease [2]
However, many of these drugs are poorly tolerated and are associated with significant adverse events
As electrons flow through the four protein complexes of the electron transport chain, they create a proton gradient that powers ATP synthase, the molecular motor that churns out massive amounts of cellular energy
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