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Some GLP1RAs (liraglutide and semaglutide) have proved to have positive effects on cardiovascular outcomes in T2DM
FangQZhengBLiuNLiuJLiuWHuangXet al
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One limitation of most PK and PD studies is the enrollment of healthy subjects, whereas the major target population for use of GLP1RAs are patients with diabetes and obesity who may have co-morbidities that might affect the PK results
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