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1 The LEADER trial (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome ResultsA Long-Term Evaluation), a large double-blind, placebo-controlled trial, recently demonstrated that liraglutide added to standard therapy for a relatively short period of time (3.5-5 years) had a significant reduction in cardiovas-cular events and mortality compared to placebo in high-risk patients (hazard ratio [HR], 0.87
AsbaghiOSadeghianMMozaffari-KhosraviHMalekiVShokriAHajizadeh-SharafabadFet al
Taking it twice a day is off-label, unsafe, and significantly raises the risk of severe insomnia, tachycardia, hypertension, and cardiac events
Resources like the 20 units conversion guide exist specifically because this confusion is so common
The most commonly reported adverse reactions to semaglutide are nausea 47%, vomiting 29%, and diarrhea 24% among others
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