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The mechanism involves IGF-1-mediated stimulation of osteoblast proliferation and enhanced collagen synthesis in bone matrix
300 Intravenous Intrajejunal 250 200 Blood Glucose (mg/dL) 150 100 50 0 -30 -15 0 15 30 45 60 75 90 105 120 135 Time (min) A Fundamental Observation: Insulin Secretion is Greater with Oral Compared to IV Glucose Blood Glucose Plasma Insulin 300 IV/IJglucose 250 200 Plasma Insulin ( pmol/L) 150 100 50 0 -30 -15 0 15 30 45 60 75 90 105 120 135 Time (min) Adapted from McIntyre N, et al
Roche and Zealand will co-commercialize the shot in the U.S
Adjustments to dosage if necessary, based on how youre responding to the injections and your symptoms
B., Portingale, J., Li, Y., & Won, Y
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