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KEY TAKEAWAYS You can have metabolic dysfunction at a normal weight with what appear to be normal labs, for example, when insulin is over suppressed from chronic under-fueling or overexercising Fasting triggers the same biological adaptation as any restrictive diet and typically results in weight regain that's 22 percent higher than starting weight Food noise is biological, not psychological, and stems from an imbalance of hormones and neurotransmitters signaling nutritional insecurity GLP-1 medications may improve immune function because metabolic health and immunity are deeply connected Shift work and chronic sleep disruption can cause real metabolic damage by weakening leptin signals, increasing insulin resistance, and amplifying hunger hormones NOTABLE QUOTE "You can't trick your body

How obesity might affect this differential gene expression pattern was not elucidated

Functional medicine addresses gut health by restoring microbiome balance, improving digestion, reducing inflammation, and identifying dietary or environmental contributors that disrupt gut integrity

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