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While both are analogs of alpha-melanocyte-stimulating hormone, they have different amino acid sequences and binding affinities

The speed advantage of Retatrutide becomes clear when you look at the weekly loss rates during peak phases

Semaglutide Side Effects (Well-Established) Common (from STEP trial data): Nausea (44%) Diarrhea (30%) Vomiting (24%) Constipation (24%) Abdominal pain (20%) Headache (14%) Serious but rare: Pancreatitis Gallbladder events (increased with rapid weight loss) Thyroid C-cell tumors (boxed warning based on animal studies) Most GI side effects are dose-dependent and improve with continued use

[Abstract] Arch Pharm Res

Open communication with your healthcare provider is essential when considering or currently taking both semaglutide and levothyroxine