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Interestingly, in trajectory 3 after 750 ns, the dynamic ECD moves back toward the TMD and is stabilized in a conformation that forms contacts mainly with ECL1, resembling the closed ECD conformation in the crystal structure

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This is actually useful information because it means dose adjustment is a viable management strategy

However, to be eligible for this medication, you must have a BMI above 30 or a BMI above 27 with certain medical conditions