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GLP-1RAs are currently used in treatment of cardiovascular diseases, neurological diseases, metabolic dysfunctions, obesity, peri operative procedures, infertility and many more (6)

A common target is around 60-80 grams daily, distributed in small amounts

Less commonly, polymorphisms in the MC1R gene (common in individuals with red hair and Fitzpatrick type I skin) reduce receptor responsiveness to exogenous agonists, requiring higher doses or longer loading phases to achieve visible results

This mechanism distinguishes Dihexa from conventional nootropics that modulate neurotransmitter systems without promoting structural brain changes