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11,12 Metformin lowers blood glucose in inadequately controlled type 2 diabetic patients by decreasing intestinal absorption of glucose, inhibiting hepatic gluconeogenesis and improving insulin sensitivity
This pathway operates independently of fat mass reduction, meaning patients may experience anti-inflammatory benefits even during early treatment phases
Overall, the role of the gut-liver axis in treating metabolic dysfunction-associated fatty liver disease by GLP-1RAs is essential
Together, they keep your blood sugar steady
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