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With doses of 10 nmol/kg and higher, rats exhibited not only a lack of activity, but also notable changes in facial expressions associated with pain and nausea including orbital tightening and nose/cheek flattening compared to rats treated with vehicle alone

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Following the Phase Ib readout, Zealand expects to initiate a mid-stage study for petrelintide imminently, with data expected by the end of 2025 or early 2026, as per the Leerink note