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The slower onset with drops likely reflects lower and less consistent systemic absorption
Both treatment approaches resulted in a mean weight loss at 52 weeks, with oral semaglutide treatment resulting in a mean weight loss from baseline of 3.8 kg and 4.7 kg in the treatment-policy estimand and trial-product estimand analyses, respectively
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Vomiting was reported in three (4%) VK2735-treated subjects
It describes semaglutide as generally showing a milder gastrointestinal profile, which may make it preferable for patients with baseline gut sensitivity
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