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Some studies found less hyperpigmentation with copper peptides
GHK-Cu has a molecular weight near 340 Da for the peptide portion, which is below the 500 Da rule of thumb for skin penetration
But even in those, the effect sizes are relatively small, and in the clinic the results are often more disappointing than the trials would suggest. Dr Whittle said due to the nature of fibromyalgia, there was unlikely to be a magic bullet or single receptor pharmacotherapeutic intervention that was broadly or substantially successful in most people with fibromyalgia
G., Hare, J
Hormone levels get out of whack, often with estrogen becoming the dominant hormone
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