At TRT Nation, we take glutathione seriouslynot because its trendy, but because the science supports it and our patients report meaningful improvements in energy, recovery, and overall resilience
All cited studies are conducted in rodent or in-vitro systems consistent with the molecule's RUO classification
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Chemosphere, 329: 138652 Payette G, Geoffroy V, Martineau C, Villemur R (2019)
Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82