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The Cochrane database of systematic reviews , (12), CD007769
Component-Level Trial Findings CJC-1295 (without DAC, modified GRF 1-29) Phase 1 and Phase 2 work described: Dose-dependent GH elevation (2-10x baseline at studied doses, PMID 16352683) IGF-1 elevation of 1.5-3x baseline at 1-2 weeks Mild facial flushing post-injection in some participants No serious adverse events at studied doses CJC-1295 with DAC The DAC-modified version covalently binds to albumin, extending half-life to 5-8 days (PMID 16352683)
Public literature is concentrated in Phase 12 trial reports and preclinical pharmacology
doi: 10.3389/fimmu.2022.784046 18 HircheFFischerMKellerJEderK
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