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The dual benefit of weight loss and glucose control makes it the obvious choice
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The choice of alternative therapy depends on individual patient factors including renal function, cardiovascular risk profile, weight management goals, hypoglycaemia risk, and patient preferences, all of which should be discussed thoroughly with the GP or diabetes specialist team
A 2025 systematic review mapped weight change after stopping anti-obesity medicines across 11 RCTs
Importantly, dulaglutide showed reduced major adverse cardiovascular events (MACE) in the REWIND trial, making it another GLP-1 RA with proven cardiovascular benefit
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