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10.1186/s12916-023-02753-6 76 ZhouH.-R.MaX.-F.LinW.-J.HaoM.YuX.-Y.LiH.-X.et al (2021)

If you notice any negative changes, its a good idea to talk to your healthcare provider to discuss your symptoms and adjust your treatment plan if needed

It has been proven that the native peptide GLP-1, GLP-1 receptor agonists and GIP-1 receptor agonists can cross the blood-brain barrier (BBB) ( The GLP-1 receptor belongs to the G protein-coupled receptor (GPCR) B family, consisting of seven transmembrane helices (TMH) interconnected by intracellular loops, with a C-terminal intracellular domain and a large (~120 amino acid) N-terminal extracellular domain (ECD) ( GLP-1 receptor is widely distributed in the CNS, including the striatum, hypothalamus, cortex, subventricular zone, and substantia nigra, as well as in the brain stem ( Studies have revealed that the expression of GLP-1 receptor is increased in neurons, GABAergic interneurons, microglia, astrocytes, and endothelial cells in the brain following the AIS ( in vivo and in vitro following a variety of injury paradigms ( The most common side effects of the GLP-1 RAs are gastrointestinal (GI)-related adverse events (AE), such as diarrhea, emesis, and nausea ( GLP-1 and GLP-1 Receptor Agonists for the Treatment of Stroke Over the past several years, neuroprotective effects of GLP-1 and GLP-1 Ras have been shown in animal models of stroke, and advances in this area have now been updated

So I was like, "Is this perimenopause or am I coming down with dementia?" I got a full blood workup done

Because the metabolic foundation was never rebuilt, appetite returns, dysbiosis persists, SCFAs remain low, and circadian signals remain disrupted