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GHK-Cu is predominantly found in saliva, blood, and urine, and has multiple biological actions when administered to test subjects, including [1]: Antioxidant gene activity [2] Suppression of inflammatory cytokine interleukin-6 [2] Increased protein accumulation [3] Increased collagen synthesis [3] In animal models, GHK-Cu has been shown to increase an anti-inflammatory proteogly called decorin that can protect diabetic rats from kidney-damaging fibrosis [2, 4]
However, inhibition of FMO3 expression led to a large accumulation of TMA, resulting in trimethylaminuria, which is better known as fish odor syndrome, and seriously affected patient quality of life (Treacy et al., 1998
International Journal of Molecular Sciences
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