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Elevated Sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis
The study reported that ebselen per se, depending on its concentration, exhibited anti-cancer activity by inhibiting the proliferating and inducing apoptosis, whereas the combinatorial treatment of ebselen and -radiation showed a synergistic increase in the extent of apoptosis (marked by upregulation of caspase-3 and down regulation of p-NF-B(p65) and p-IB)
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American Journal of Physiology Endocrinology and Metabolism
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