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Meanwhile, this also demonstrates that the mechanism of action of TCM is not limited to the direct antagonistic effects on disease foci, but also encompasses cross-organ, trans-system, and remote indirect regulatory effects mediated through the modulation of intermediary substances such as GM metabolites

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Besides the interleukin family, other genes related to the skin inflammatory mechanism were also upregulated

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Considering the mechanistic overlap in the development and progression of CKD in type 1 and type 2 diabetes, there exists a strong rationale for simultaneously developing novel CKD therapies for use in both type 1 diabetes and type 2 diabetes and studying the repurposing of existing type 2 diabetes CKD therapies for the treatment of CKD in people with type 1 diabetes