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For instance, MC4R intracerebroventricular administration has been shown to induce the gene transcription of cortisol releasing hormone with effects blocked by administration of an MC4R antagonist [42]
Lead-in period Eligible participants were enrolled in a 12-week intensive lifestyle intervention lead-in period
Improved glycemic control
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Human studies have not shown the same effect, but the family-history exclusion for medullary thyroid cancer is kept in place as a precaution
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