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The patients were randomized to receive either lofexidine or placebo for management of opioid withdrawal symptoms

Mechanistically, hyperglycemia-induced miR-338-3p upregulation represses SLC1A5 expression, thereby impairing antioxidant capacity and triggering oxidative stress-mediated ferroptosis, which in turn exacerbates BRB damage and oxidative stress to form a oxidative stress-BRB impairment-ferroptosis positive feedback loop that drives DR progression