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The skin becomes visibly thinner, loses elasticity, and becomes prone to damage
48 IlicS.DrmicD.FranjicS.KolencD.CoricM.BrcicL.et al (2011a)
doi:10.3390/molecules30010043 155
Cyanocobalamin: usually room temperature Cyanocobalamin is generally stable at controlled room temperature, away from heat and direct sunlight, though you should still check the BNF entry and the product leaflet for the exact storage line
The practical point for a reader is the opposite of the research-chemical instinct that more milligrams means more effect
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