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72 CAR T-cell therapy directly targets tumor surface antigens via engineered CARs, completely bypassing the tumor cell-intrinsic MHC class I antigen presentation pathway, whereas CAR-NK cell therapy integrates CAR-directed cytotoxicity with the innate missing-self recognition of NK cells, enabling efficient elimination of tumor cells with downregulated or absent MHC class I expression and thereby directly addressing resistance mechanisms
While chapped lips can be irritating and sometimes painful, especially if the skin begins to crack and bleed, the condition is typically not dangerous
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[4] It appears to further lack the proposed implications sometimes seen with hGH supplementation, such as long-bone growth, reduced sensitivity to insulin, and edema
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