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As far back as the 1970s, there were case reports in the literature of B12 deficiency associated with metformin use, with several observational studies reporting the same, but very little in the way of high-quality, well-powered, prospective studies

If you encounter side effects, discuss it with vet and give plenty of water to your cat

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May Help Brain Function While B12 cant necessarily improve your brain function on its own, it can help to prevent the loss of neurons associated with memory reduction