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Moreover, TB-500 also appeared to have promoted the expression of CD31, -smooth muscle actin (-SMA), Ang2, tie2, VEGFA, N1ICD, and p-p65 in the muscle tissues of murine CLI models

Cobalamin blood levels can be monitored, and many veterinarians prefer to check these levels at the time of diagnosis for GI disease, as well as periodically during treatment, to determine if B12 levels are remaining normal

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When clinically appropriate, B12 supplementation may be recommended as part of a medical evaluation

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