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This structural modification strategy has been pivotal in the development of GLP-1 receptor agonists with extended plasma half-lives [17]

This leads to fermentation and gas production, which can cause more burping

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These medications are contraindicated in patients with: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) For patients with standard hypothyroidism (typically autoimmune thyroiditis or post-ablation), these contraindications do not apply