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In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes

Careful monitoring may be warranted to distinguish disease flares from medication-related effects

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Gastroenterologists typically assess fecal calprotectin, endoscopic findings, and symptom severity to establish a clear baseline

Therefore, they use small doses to help their body adjust, maintain weight, or ease into therapy in a way that seems more manageable