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These findings were confirmed in a meta-analysis of three randomized clinical trials (n = 2234) in which resmetirom significantly reduced hepatic fat by magnetic resonance imaging-proton density fat fraction (MRI-PDFF) with 80 mg (27.74% at 36-52 weeks and 30.92% at 12-16 weeks) and with 100 mg (36.05% and 36.89%