The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases
Journal of Neuroscience, 25(49), 11489-11493
doi: 10.1111/febs.12546 136 TuoQZLiuYXiangZYanHFZouTShuYet al
It must be calibrated according to good weighing practices
The increased production of pro-inflammatory cytokines, such as interleukin 1 or interleukin 8, greatly impacts the biological function of the cells, resulting in skin lesions and deterioration of skin appearance, as well as the accumulation of eumelanin, leading to the formation of skin spots