Reported side effects from clinical practice: Contraindications: Pregnancy, breastfeeding, active cancer, and known hypersensitivity
Autoxidation occurs at physiological pH and is initiated by the surrounding free radicals, which autoxidize the phenolic hydroxyls on the curcumin molecule (74)
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Functional brain imaging studies have reported a decrease in synaptic connectivity and neuronal circuitry in the PFC and hippocampus in depressed patients (Perlman et al., 2012
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