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Through such comprehensive genetic analyses, PRSs holds the potential to advance our ability to tailor preventive and therapeutic strategies based on individual genetic risk profiles, paving the way for precision medicine for IR-psychiatric multimorbidity

A large real world evidence demonstrated that when comparing several GLP-1 receptor agonists versus DPP-4 inhibitors treatments in patients with a baseline cardiovascular risk, the incidence of adverse events was much lower for the former [8]

most patients lose 510% of baseline weight Months 612: Peak weight loss typically occurs, with some patients losing 1015% or more of initial body weight in clinical trials, particularly on higher-efficacy agents like semaglutide 2

Data on study characteristics, outcomes, and effect sizes were extracted

Drug Metab Rev