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A clinical decision should not be tied to a fake clock

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Indeed, both CBS and CSE can synthesise cysteine persulphide (CysSSH) and poly-sulphides (CysS ( n ) SH) from cystine, 104,136 whereas 3-MP-activated 3-MST can generate from cysteine, glutathione or n -acetylcysteine, the corresponding per-sulphides (respectively, CysSSH, GSSH and NACSSH)

So, the broader question is whether it is both clinically and economically better to aggressively treat certain high-risk obese patients sooner, or risk downstream cost and clinical complexity later

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