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Laxity and fat loss can lead to extra tissue in that area, which is definitely bothersome." Some studies also show that rapid weight loss from GLP-1 medications can lead to a decrease in lean muscle mass

Table 1 Efficacy of GLP-1 agonists efficacy (adapted from UpToDate) (44)

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Semaglutide primarily works by activating the GLP-1 receptor, which helps regulate appetite, satiety, food noise, gastric emptying, and blood sugar-related signaling

It helps transport these fatty acids into the mitochondria, which are burned for energy