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[118] Methionine synthase [edit] Methionine synthase, coded by MTR gene, is a methyltransferase enzyme which uses the MeB 12 and reaction type 2 to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine

Both variants had not previously been described and were classified as pathogenic according to the American College of Medical Genetics (ACMG) guidelines [13]

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* Liver and Kidney markers: Ensures that synthetic compounds are not causing systemic strain

Circadian misalignment increases cardiovascular disease risk factors in humans