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SUSTAIN-6 (cardiovascular outcomes in T2D, Marso et al., NEJM 2016) reported a 26% reduction in MACE versus placebo over 104 weeks, the original cardiovascular signal that established the GLP-1 class's broader metabolic-protection profile beyond glycaemic control
EBioMedicine 49:318330
Retatrutide, a GIP, GLP-1, and Glucagon Receptor Agonist, for People with Type 2 Diabetes: A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trial. The New England Journal of Medicine
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