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One study, completed in 2018, compared tirzepatide directly to dulaglutide: Results found that tirzepatide showed significantly better efficacy with regard to glucose control and weight loss than did dulaglutide, with an acceptable safety and tolerability profile. Side effects with tirzepatide were similar to those of dulaglutide and, in general, the drug was well tolerated
00:12:06 Vickie Danaher For example, orforglipron shouldnt be used with strong CYP3A4 inducers, such as carbamazepine, since this may reduce orforglipron drug levels and effectiveness
Consequently, evidence regarding Wegovy's effects in this subgroup remains largely observational or anecdotal
Comparative effectiveness of semaglutide versus liraglutide, dulaglutide or tirzepatide: A systematic review and meta-analysis
Experts warn that cheaper semaglutide could dramatically reshape prescribing patterns, insurance coverage, and public health strategies, especially given soaring demand for GLP1 treatments and the heated debate over their use for both medical and cosmetic weight loss
