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During the Zepbound lead-in treatment period, the most frequent adverse events were nausea (35.5%), diarrhea (21.1%), constipation (20.7%) and vomiting (16.3%)

Human Data: While animal studies (mostly in rats) are overwhelmingly positive, large-scale, peer-reviewed human clinical trials are still limited

Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the [PMID: 36099415] Laboratory literature summary: Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the NAMPT-NAD+ pathway

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