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This combination approach works particularly well for athletes dealing with heavy training loads, competing in multi-day events, or preparing for major competitions

This imbalance, known as dysbiosis, can increase inflammation and intestinal permeability

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Loss of small bowel epithelial cell mass results in impaired intestinal permeability and in declined circulating levels of citrulline, as is shown in haemopoietic stem cell transplant recipients suffering from severe oral and gastrointestinal mucositis following intensive myeloablative therapy [158]